Innovent Biologics (Suzhou) Co., Ltd.

Innovent Biologics Co., Ltd.

Shuaixiang Zhou

Junjian Liu

Li Li

Zhiyuan Li

Xinzhen Shi

Enkun Zhou

Lishan Kang

Fenggen Fu

Tianhang Zhai

Chunyin Gu

Dechao Yu

Min Wu

The present invention relates to a novel interleukin-2 (IL-2) mutant protein and use thereof. In particular, the present invention relates to an IL-2 mutant protein with reduced IL-2Rα receptor binding ability and/or increased IL-2Rβ receptor binding ability compared with the wild-type IL-2. The present invention further provides a fusion protein and an immunoconjugate comprising the IL-2 mutant protein, a nucleic acid encoding the IL-2 mutant protein, and a vector and a host cell comprising the nucleic acid. The present invention further provides a method for preparing the IL-2 mutant protein, a pharmaceutical composition comprising the IL-2 mutant protein, and therapeutic use of the mutant protein.

Interleukin-2 and use thereof

The present invention relates to a novel antibody and an antibody fragment thereof that specifically bind to IL-23p19 and a composition comprising the antibody or the antibody fragment thereof. In addition, the present invention relates to a nucleic acid encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acid, and related use. Furthermore, the present invention relates to therapeutic and diagnostic use of the antibody and the antibody fragment.

Anti-IL-23p19 antibody and use thereof in treating diseases

The invention relates to a novel antibody and an antibody fragment thereof specifically binding to a B-cell maturation antigen (BCMA), and particularly relates to a fully humanized single-chain variable fragment (scFv). The invention further relates to a nucleic acid encoding the antibody, a vector, and a host cell expressing the nucleic acid. Furthermore, the invention also relates to a composition containing the antibody described herein, and use thereof in treatment and diagnosis.

Fully humanized anti-B cell maturation antigen (BCMA) single-chain antibody and use thereof

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Jiangsu, China

Shuaixiang Zhou