Nanjing Legend Biotech Co., Ltd.

Jiangsu University

Chinese Academy of Sciences

Legend Biotech Ireland Limited

Shuai Yang

Shu Wu

Chuan-Chu Chou

Yafeng Zhang

Wang Zhang

Yuanyuan Peng

Weidong Jia

Guoming Liu

Sheng Guo

Kun Xu

Liusong Yin

Mingxiong Ou

Jian Liu

Zhaoyang Zhang

Xueren Dai

Huitao Zhou

Feng Lin

Ying Liu

Yucheng Wu

Xinpo Jiang

Ming Wang

Yongming Luo

Chen Tu

Douyan Zhao

Shiqun Dai

An Tang

Fei Sun

Tao Zhao

Sujuan Wang

Ruidong Hao

Qing Dai

Kun Jiang

Qi Pan

Provided herein are anti-DLL3 chimeric antigen receptors (CARs), DLL3 binding proteins and uses of such CARs or DLL3 binding proteins in the treatment of DLL3 associated disorders, such as small cell lung cancer.

Anti-DLL3 chimeric antigen receptors and uses thereof

The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes PD-L1. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen binding fragment thereof.

Antibodies and variants thereof against PD-L1

The present application provides anti-LAG-3 constructs comprising a single-domain antibody (sdAb) that specifically recognizes LAG-3. Also provided are methods of making and using these constructs.

Single-domain antibodies against LAG-3 and uses thereof

Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-β receptor II (dnTGFβRII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Anti-mesothelin chimeric antigen receptor (CAR) constructs and uses thereof

A model for predicting bioavailability of arsenic in site soil and a construction method and an application thereof, includes steps of: leveling soil after selecting a measuring point, vertically placing a measuring sleeve, fully supplying water to site soil to be measured, balancing for 20-40 min, measuring a water content in a soil volume not less than 40%, placing a piston DGT device into the measuring sleeve and pressing the device into soil, covering a top of the measuring sleeve with a wind shield, cleaning the piston DGT device after the measurement, analyzing a concentration of available arsenic by ICP-MS, and measuring available arsenic of soil; linearly fitting the available arsenic measured by a DGT method with human bioavailable arsenic measured by a UBM method, and obtaining a model for predicting bioavailability of arsenic in site soil.

Model for predicting bioavailability of arsenic in site soil and construction method and application thereof

Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against TIGIT

Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against PD-1

The present application provides an antibody, such as a monoclonal antibody (mAb), or an antigen binding fragment thereof, that specifically recognizes TIGIT. Also provided are pharmaceutical compositions, or methods of making and using the antibody or antigen-binding fragment thereof.

Antibodies and variants thereof against TIGIT

The present invention relates to a method for detecting a thickness of a tree canopy based on an ultrasonic echo signal, and belongs to the technical field of agricultural machinery information sensing and detection. The present invention analyzes and discriminates a first effective peak and a last effective peak of the ultrasonic echo signal, obtains a first effective peak time and a last effective peak time, and calculates the thickness of the tree canopy according to a provided calculation formula, thus realizing the direct detection of the thickness of the tree canopy. This method has characteristics such as a high accuracy and a wide application range, and is applicable to the field of detection of the thickness of a tree canopy in industries such as agricultural machinery and forestry machinery.

Method for detecting thickness of tree canopy based on ultrasonic echo signal

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against PD-L1

The present invention discloses a method and a device for laser-assisted electrochemical composite deposition using a rifling-type hollow rotating electrode, which relate to the field of micro-composite processing in special processing technologies. A center of a laser beam is allowed to pass through a rifling-type hollow rotating electrode and focus onto a cathode substrate. When the rifling-type hollow rotating electrode is rotated at a constant speed, an electrodeposition solution rotates in the rifling-type hollow rotating electrode and generates a certain centripetal force to improve the precision and localization of deposition. During the process of the present invention, an internal rifling structure of the electrode is rotated at a high speed so that the deposition solution generates a centripetal force. The internal rifling structure and an external helical structure of the rifling-type hollow rotating electrode make the deposition solution move upward to form a 'self-circulation' system.

Method and device for laser-assisted electrochemical composite deposition using rifling-type hollow rotating electrode

Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.

Compositions and methods using a single-domain antibody binding transferrin and protein A for increasing protein half-life in serum

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Also provided are methods of making and using these constructs.

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Nanjing, China

Shuai Yang