National Health Research Institutes

Taigen Biotechnology Company, Ltd.

Other

Taigen Biotechnology

Shu-Jen Chen

Chu-Chung Lin

Ming-Chu Hsu

Chi-Hsin Richard King

Wen-Tai Li

Der-Ren Hwang

Chiung-Tong Chen

Chi-Feng Yen

Chien-Huang Wu

Ying-Huey Huang

Yibin Xiang

Chih-Wei Chang

Ming-Chen Chou

Cheng-Kung Hu

Chen-Tso Tseng

Hua-Chien Chen

Pei-Chin Cheng

Jen-Fuh Liu

Jiing-Jyh Jan

Shin-Ru Shih

Kak-Shan Shia

Jyh-Haur Chern

Gholam Hossein Hakimelahi

Chung-Ming Chang

Jen-Hao Cheng

Chen-Huang Hsieh

Luke Lin

Pei-Jia Yang

Ying-Ja Chen

This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.

Ranking system for immunogenic cancer-specific epitopes

This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula: 

Treatment of antibiotic-resistant bacteria infection

This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject in need thereof an effective amount of one or more compounds of formula (I). Each variable in this formula is defined in the specification. 

Pyrimidine compounds

This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R, R, R, R, and n are defined herein.

Methods of 1H-indol-3-yl-2-oxoacetamide compounds

This invention relates to methods for treating retinopathy and repairing tissue damage. The methods include administering to a subject in need thereof an effective amount of one or more compounds of the following formula. Each variable in this formula is defined in the specification. 

Polyamine compounds

A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R, R, R, R, and n are as defined herein.

Use of 1H-indol-3-yl-2-oxoacetamide compounds

This invention relates to treating inflammatory and immune diseases with certain aminoquinoline compounds that bind to CXCR3 receptors. The aminoquinoline compounds are covered by the formula (I) shown below. Each variable is defined in the specification. 

Aminoquinoline compounds

The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula.In this formula, each Ris independently isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 1,3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R; or when taken together with Rand the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R. Each Ris independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R; or when taken together with Rand the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R. Each Ris independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R. Each Ris independently H, NO, halo, CN, R, OR, COR, SR, NRR, C(O)R, C(O)NRR, OC(O)R, S(O)R, S(O)NRR, NRC(O)NRR, NRC(O)R, NR(COOR), NRS(O)NRR, NRS(O)R, or S(O)OR.

Indol-3-YL-2-oxoacetamide compounds and methods of use thereof

A heat sink attached externally on a bottom portion of a portable computer has the heat sink placed at a rear lower aspect of the portable computer; the present invention is characterized that the heat sink is a flat casing; at least one fan is installed inside the heat sink; an air inlet is disposed at the upper aspect of the fan; an air outlet is disposed at the front aspect of a bearing plate on the front aspect of the fan; a current guide board is disposed at the lower aspect of the fan; according to the abovementioned structure, when being used, the air current enters from the air inlet and discharges outwardly from the air outlet thereby allowing the cooling air current to enter from the bottom portion of the portable computer for heat dissipation.

Heat sink attached externally on bottom portion of portable computer

Imidazolidinone compounds

Growing community of inventors

Taipei, Taiwan

Shu-Jen Chen