Roche Palo Alto LLC

Syntex (u.s.a.) Inc.

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Shu-Hai Zhao

Jacob Berger

Robin D Clark

Francisco Javier Lopez-Tapia

Nancy Elisabeth Krauss

Keith Adrian Murray Walker

Meng Sui

Lee Allen Flippin

Robert J Greenhouse

Saul Jaime-Figueroa

Joan Marie Caroon

Aubry Kern Miller

David George Putman

Klaus Kurt Weinhardt

Yanzhou Liu

Ryan Craig Schoenfeld

Weiya Yun

Adrian Wai-Hing Cheung

Dov Nitzan

Hongying Yun

Counde O'Yang

Lisha Wang

Hans Maag

Christine E Brotherton-Pleiss

Lu Gao

Song Feng

Joe Timothy Bamberg

Lee Edwin Lowrie, Jr

Steven Sethofer

Douglas William Bonhaus

Renee Sharon Martin

Di Hong

Li Zhang

Robin Douglas Clark

Jr Lee Edwin Lowrie

The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Antiviral compounds

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, R, A, Aand Aare as described herein, compositions including the compounds and methods of using the compounds.

Indazoles for the treatment and prophylaxis of respiratory syncytial virus infection

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R, R, R, R, R, R, R, R, R, Y, Z, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

Benzoxazine derivatives and uses thereof

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

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Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Dihydropyridone amides as P2X7 modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, p, q, Ar, R, R, Rand Rare as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

Chroman derivatives and uses thereof

Compounds of the formula I: wherein m, n, p, X, Ar, R, R, R, Rand Rare as defined herein. Methods of making the compounds and using the compounds for treatment of 5-HT6 receptor-mediated diseases are disclosed.

Compounds of formula I or formula II: or pharmaceutically acceptable salts thereof, wherein m, n, p, Ar R, R, R, and Rare as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds.

Indole and benzofuran 2-carboxamide derivatives and uses thereof

Compounds of the formula I: or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein k, m, n, p, q, X, Y, Z, Ar, R, R, Rand Rare as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

Benzoxazine and quinoxaline derivatives and uses thereof

Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R, R, R, R, Rand Rare as defined herein. Also provided are compositions comprising, methods of preparing, and methods of using the subject compounds.

Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists

Compounds of the formula I: and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is &#x2014;(CRR)&#x2014;, A is &#x2014;NR, m is 2, n is 1, q is 2, Ris optioinally substituted aryl or optionally substituted heteroaryl, and p, R, R, R, R, R, R, R, R, and R, are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of central nervous system diseases.

Quinazolinone and benzoxazinone derivatives and uses thereof

Growing community of inventors

Cupertino, CA, United States of America

Shu-Hai Zhao