Tsinghua University

Shu-Chuan Lin

Margaret Dah-Tsyr Chang

Wei-I Chou

Yuh-Ju Sun

Ping-Chiang Lyu

Tan-chi Fan

Shun-Lung Fang

Yuan-Chuan Lee

Rong-Yuan Huang

Shi-Hwei Liu

A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of XNNNXXNYQXXXXXwherein the Xand Xmean a pair of opposite charged amino acid residues, and the X, X, X, X, X, or Xmeans an amino acid residue is described. A mixture for diminishing a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.

Polysaccharide-protein binding model and nano-fibril formation of a starch binding domain

The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.

Method of using heparin binding motif for treating asthma

A cell penetrating peptide which has following sequence: NYBXBXBNQX, wherein B represents a basic amino acid, Xrepresents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, Xrepresents any amino acid, and Xrepresents N or none is described. A method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject is also described.

Cell penetrating peptides for intracellular delivery

The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.

Method for the detection of human immunodeficiency virus envelope (HIV) glycoprotein utilizing carbohydrate binding module (CBM) 20 or 21

A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.

A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.

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Hsinchu, Taiwan

Shu-Chuan Lin