Piramal Life Sciences Limited

Shruta Sudheer Dadarkar

Somesh Sharma

Swati Bal-Tembe

Asha Adrian Kulkarni-Almeida

Sapna Parikh

Ravindra Dattatraya Gupte

Ashok Kumar Gangopadhyay

Vijay Singh Chauhan

Ashish Suthar

Nilesh Dagia

Aditi Amol Tannu

Dhananjay Sapre

Mahesh Gundaji Jadhav

This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant,. The said extract ofcontains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-(TNF-&#x3b1;) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1), vascular-cell adhesion molecule 1 (VCAM-1), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti-inflammatory agent or can be used in combination with at least one anti-inflammatory agent.

Herbal composition for inflammatory disorders

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Mumbai, India

Shruta Sudheer Dadarkar