Cardiac Pacemakers, Inc.

Boston Scientific Scimed, Inc.

University of Washington

Shrojalkumar Desai

Brian L Schmidt

G Shantanu Reddy

Mark W Boden

Daniel J Cooke

Mohan Krishnan

Michael C Smith

Leslie J Carion

Marlene C Schwarz

Frederick H Strickler

Larry L Hum

Arthur J Foster

Ronald W Heil, Jr

Brendan Early Koop

David R Wulfman

James P Rohl

Devon N Arnholt

Buddy D Ratner

Patrick Willoughby

Jeannette C Polkinghorne

Matthew S Finlay

Peter J Wolf

Harshad M Borgaonkar

Jared Rud

Steve DeRoche

Shantanu Reddy

Jan Seppala

Jr Joseph T Delaney

Arthur J Forster

Steve Zhang

In accordance with various aspects of the invention, copolymers comprising styrene and isobutylene monomers are used in the construction of implantable and insertable medical devices for electrical stimulation, including, for example, electronic signal generating components and electrical leads for such devices.

Styrene-isobutylene copolymers and medical devices containing the same

A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

Surface modification to improve lubricity, abrasion resistance and temperature resilience of leads

The present invention is directed to a medical electrical lead including an insulative lead body formed, at least in part, from a polyisobutylene urethane, urea or urethane/urea copolymer. In some applications, the lead body can include at least one outer tubular insulator and/or an inner elongated member formed from a polyisobutylene urethane, urea or urethane/urea copolymer. Portions of the lead body formed form the polyisobutylene urethane, urea or urethane/urea copolymer can be either extruded or molded.

Medical devices including polyisobutylene based polymers and derivatives thereof

The present invention pertains to crosslinkable and crosslinked polyisobutylene-based polymers, to compositions that contain such polymers, and to medical devices that are formed using such polymers. According to one aspect, the present invention pertains to crosslinkable and crosslinked compositions that comprise a copolymer that comprises a polyisobutylene segment and two or more reactive groups. According to another aspect, the present invention pertains to medical devices that contain such compositions. According to another aspect, the present invention pertains to methods of making medical devices using such compositions.

Crosslinkable polyisobutylene-based polymers and medical devices containing the same

A medical electrical lead includes a conductive polymer conductor fabricated from a conductor-filled polyisobutylene urethane, urea or urethane/urea copolymer.

Lead having a conductive polymer conductor

The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.

Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same

The present invention provides medical devices that contain polyisobutylene urethane copolymers, polyisobutylene urea copolymers and polyisobutylene urethane/urea copolymers. More particularly, the present invention provides medical leads that contain such copolymers.

Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same

Biocompatible amino acid anhydride polymers for use in tissue engineering, and methods for their preparation and use.

Biocompatible amino acid anhydride polymers

A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

Implantable lead with flexible tip features

Some embodiments relate to a method of implanting a cardiac lead. An expansion module is implanted in a target region within vasculature, the target region being defined by a portion of a brachiocephalic vein and a portion of a corresponding subclavian vein. The expansion module is transitioned from a collapsed state to an expanded state within the target region to contact the vasculature. A cardiac lead is implanted through the expansion module, the cardiac lead defining an intermediate section corresponding to the target region. The intermediate section of the cardiac lead includes a surface treatment adapted to reduce at least one of cell proliferation, thrombosis, fibrosis, and inflammation at the target region.

Systems and methods for transvenous lead implantation

Growing community of inventors

Little Canada, MN, United States of America

Shrojalkumar Desai