Orchid Chemicals & Pharmaceuticals Limited

Mmv Medicines for Malaria Venture

Allecra Therapeutics Gmbh

Orchid Pharma Ltd.

Shridhar Narayanan

Gopalan Balasubramanian

Sanjeev Saxena

Ganapavarapu Veera Raghava Sharma

Sukunath Narayanan

Sriram K Rajagopal

Ravikumar Tadiparthi

Sukumar Sakamuri

Senthilkumar Udayampalayam Palanisamy

Venkatesan Parameswaran

Virendra Kachhadia

Shahul Hameed Peer Mohamed

Uma Ramachandran

Maneesh Paul-Satyaseela

Sridharan Rajagopal

Durairaj Peter Bhakiaraj

Gajanan Shanbhag

Maruthikumar Narayanam

Venkatesan Janarthanam

Sathyanarayana Gadde

Sathya Narayana Thara

Santosh Vishwakarma

Hariharan Periasamy

Gajendra Singh

Sudhir Landge

Franklin Pooppady Xavier

Jeganatha Sivakumar Balasubramanian

Agneeswari Rajalingam

Nilanjana Roy Choudhury

Jayanarayan Kulathingal

Anandkumar Raichurkar

Sivanesan Dharmalingam

Jeyamurugan Mookkan

Jayashree Puttur

Thirunavukkarasu Sappanimuthu

Visweswara Akella Satya Surya Srinivas

Krishna Koushik

Kilambi Narasimhan

Aravind Appu

Pravin Iyer

Om Reddy Gaddam

Senthilnathan Manickam

Vasan Kirthika Sambandamurthy

Suresh Solapure

Narayanan Surendran

Lolaknath Santosh Vishwakarma

Vikas Patil

Kannan Murugan

Lavanya Andiappan

Eknath Vithalrao Bellale

Saravanan Thirunavukkarasu

Surendran Narayanan

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as &#x3b2;-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of &#x3b2;-lactamases. These compounds restore/potentiate the activities of &#x3b2;-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting &#x3b2;-lactamases. Formula (I) 

Compounds and their use

The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and/or prevention of malaria caused byspecies, and to their methods of preparation.

Triaminopyrimidine compounds useful for preventing or treating malaria

Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

Heterocyclic compounds as phosphodiesterase inhibitors

Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol, triglyceride levels; treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis, rheumatoid arthritis; treatment and/or prophylaxis of type II diabetes. These compounds are more particularly dipeptidyl peptidase (DPP IV) inhibitors. 

Dipeptidyl peptidase IV inhibitors

Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases. 

Pyrimidine compounds and their uses

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Chennai, India

Shridhar Narayanan