Lupin, Inc.

Shridhar Keshav Adurkar

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Neelima Sinha

Navnath Popat Karche

Anil Kashiram Hajare

Gourhari Jana

Ajay Ramchandra Tilekar

Baban Rupaji Thube

Dnyaneshwar Changdeo Bhanage

Bikramjit Singh Lairikyengbam

Firoj Aftab Raje

Disclosed are compounds of the Formula (I), wherein R, R, R, R, R, R, Rand m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the &#x3b1;7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia. 

Pyrrole derivatives as alpha 7 NACHR modulators

Disclosed are compounds of the formula (I), wherein R, R, R, R, R, R, Rand m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the &#x3b1;7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia. 

Pyrrole derivatives as alpha 7 nAChR modulators

Disclosed is a compound of formula (I) wherein Y, Ring D, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Thiazole derivatives as alpha 7 nAChR modulators

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Pune, India

Shridhar Keshav Adurkar