Nokia Technologies Oy

Rutgers, the State University of New Jersey

Shreyas Shah

Ki-Bum Lee

Mingde Zheng

Michael Scott Eggleston

Aniruddh Solanki

Michael Eggleston

The application relates to an apparatus which comprises at least one portion of artificial skin () and a plurality of sensors () dispersed within the at least one portion of artificial skin (). The plurality of sensors () have at least one physical property which is configured to be modified when the plurality of sensors () are exposed to a parameter such that the modification of the physical property can be detected by an external detector (). The application also relates to detection systems comprising such apparatus.

Artificial skin

A perfusive tissue phantom is disclosed. An example tissue phantom includes a chamber with fluid inlets disposed on a first side and fluid outlets disposed on a second side spaced apart from the first side. The tissue phantom also includes a hydrogel region connected to at least one of the fluid inlets and including a permeable hydrogel with structural characteristics that simulate a type of tissue. The tissue phantom also includes a microfluidic conduit coupled to at least one of the fluid inlets. The microfluidic conduit is a flexible, semi-permeable fiber that simulates a blood vessel. The structural characteristics of the permeable hydrogel may include a selected density, porosity, rigidity and dimension that approximate a target density, porosity, rigidity and dimension of interstitial space of the type of tissue.

Perfusive tissue phantom

A functionalised particle, wherein the particle has a first optical spectral signature in a first structural configuration of the particle and a second optical spectral signature in a second structural configuration of the particle.

Functionalised particles

This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).

Stem cell differentiation using novel light-responsive hydrogels

This application discloses a nanotopography-mediated reverse uptake (NanoRU) platform useful for intracellular delivery of nucleic acids into mammalian cells, in particular stem cells, as well as methods of preparation and applications thereof. In particular, this system can be used to deliver small interfering ribonucleic acids (siRNAs) into neural stem cells and enhance neuronal differentiation of the stem cells.

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Dayton, NJ, United States of America

Shreyas Shah