The Green Cross Corporation

Kaken Pharmaceutical Company, Ltd.

Shozoh Masumoto

Kazumasa Yokoyama

Tadakazu Suyama

Yutaka Mizushima

Yoshinobu Hashimoto

Katsuhiro Uchida

Hiroyuki Okamoto

Masao Tohno

Kiichiro Nabeta

There is provided a fat emulsion of an ester of flurbiprofen having the formula ##STR1## wherein R is a group of the formula ##STR2## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, R.sub.2 is a C.sub.1 -C.sub.15 alkyl group or a C.sub.2 -C.sub.8 alkenyl group, and m is zero or an integer of 1; or a lactone group of the formula ##STR3## wherein R.sub.3 and R.sub.4 are same as or different from each other and are a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and n is an integer of 1 or 2. The emulsion containing particles of a vegetable oil dissolving the ester can be orally or parenterally administered to human or animal for analgesia, antiphlogosis and antipyresis in various diseases and exhibits a high activity with small amounts in terms of flurbiprofen as compared with flurbiprofen itself.

Ester of flurbiprofen and emulsion containing the same

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Shiga, Japan

Shozoh Masumoto