Yamanouchi Pharmaceutical Company Ltd.

Sanraku Incorporated

Biomaterials Universe, Inc.

Shozo Muranishi

Shokyu Gen

Yoshito Ikada

Hiroshi Yoshikawa

Hitoshi Sezaki

Polylactic acid microspheres having an average particle diameter of about 0.1 to 10 .mu.m which are produced from solution containing a physiologically active substance by the solvent-evaporation drying process. The microspheres are produced by emulsifying the solution in a non-solvent by the aid of ultrasonic wave. The microspheres produce a sustained release effect of the physiologically active substance.

Polylactic acid microspheres and process for producing the same

A micellar solution composition for rectal use comprising (a) a water-soluble drug which is poorly absorbable on oral administration (b) a middle-higher fatty acid and/or the mono- or di-glyceride thereof, (c) a bile acid and/or a nonionic surface active agent, and (d) water; and a powder composition for rectal use prepared by drying the aforesaid micellar solution composition.

Compositions for rectal use

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Kyoto, Japan

Shozo Muranishi