The Royal Institution for the Advancement of Learning / Mcgill University

Mcgill University

Showan Nazhat

Benedetto Marelli

Jake E Barralet

Antonio Alessandrino

Giuliano Freddi

Chiara Ghezzi

William Cole Lepry

Neysan Nejat Oliver Kamranpour

Borate-glass biomaterials comprising: aNaO. bCaO. cPO. dBOwherein a is from about 1-40 wt %, b is from about 10-40 wt %, c is from about 1-40 wt %, and d is from about 35-80 wt %; and wherein the biomaterial has a surface area per mass of more than about 5 m/g. Methods of making and uses of these biomaterials.

Borate-glass biomaterials

A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel

There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.

Dense hydrogels

Growing community of inventors

Montreal, Canada

Showan Nazhat