Japan Science and Technology Agency

Shouichirou Ozaki

Katsuhiko Mikoshiba

Akinobu Suzuki

Akiko Terauchi

Etsuko Ebisui

Jun-ichi Goto

Kozo Hamada

The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein Ris a substituted or unsubstituted aryl or heterocyclyl group, R, R, and Rare hydrogen atoms, n is 2, X is halogen, Rand Rindependently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein Rand Rare not hydrogen atoms at the same time, or Rand Rmay be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

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Saitama, Japan

Shouichirou Ozaki