Ajinomoto Co., Ltd.

Shouichi Kondou

Satoji Takahashi

Mitsuhiko Kojima

Tatsuya Ishikawa

Yoshinori Ogawa

The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m/g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m/g or more and the particle size of the noble metal is 8.0 nm or less, wherein Ris hydrogen or a protective group, Ris NHor OH, Ris an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.

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Yokkaichi, Japan

Shouichi Kondou