Institute of Radiation Medicine, Academy of Military Medical Sciences, Pla.

Institute of Radiation Medicine, China Academy of Military Medical Sciences Pla

Hainan Yangpu New & Special Medicine Co., Ltd.

Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China

Shouguo Zhang

Lin Wang

Tao Peng

Lu Yan Li

Wei Li

Jing Liu

Ling Han

Xiaoming Yang

Shengqi Wang

Teng Luo

Jianping Ren

Xiaoxue Wen

Fengsheng Che

Yiguang Jin

Xiaowei Zhu

Qiujun Lu

Haiyan Yan

Yiqun Zhan

Changyan Li

Shangri Wang

Fengsheng Room 2501 Che

Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.

Substance having tyrosine kinase inhibitory activity and preparation method and use thereof

The present invention relates to C-Glycosylisoflavones having alkylaminoalkoxyl substituent and pharmaceutically acceptable salts thereof, a process for the preparation thereof, pharmaceutical compositions comprising an effective amount of a compound of the formula (I), and to the use of these compounds or compositions for the treatment or prevention of cardio- and cerebrovascular diseases, in particular for the treatment of various cardiocerebral hypoxic-ischemic diseases, for the treatment or prevention of diabetes mellitus and complications thereof, and for the treatment or prevention of chemical poisoning, in particular alcoholism.

C-glycosylisoflavones having alkylaminoalkoxyl substituent, preparation and use of the same

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Shouguo Zhang