Fujifilm Corporation

Shotaro Ogawa

Aya Mochizuki

Toshihiro Usa

Yanlong Che

Kenichiro Tamaki

Kazunori Komatsu

Takayoshi Oyamada

Atsushi Fujita

Ryuichi Katsumoto

Kenji Ichikawa

Seiji Kasahara

Keio Okano

Satoshi Chai

Kozue Ikeda

Junya Yoshida

Shinichiro Okada

Ryo Hibino

Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.

Production method of mold having recessed pattern, and manufacturing method of pattern sheet

A production method of a mold includes: preparing a plate precursor having a protruding pattern formed of protrusions in a pattern presence region on a base, and a thermoplastic resin sheet; determining a position at which the plate precursor is to be pressed against the thermoplastic resin sheet by moving the plate precursor and the thermoplastic resin sheet relative to each other; and forming a recessed pattern on the thermoplastic resin sheet by pressing the protrusions of the plate precursor which is heated against the thermoplastic resin sheet at a position where a part of the pattern presence region of the plate precursor excluding the protrusions is separated from a surface of the thermoplastic resin sheet, cooling the plate precursor in a state in where the pressed protrusions and the thermoplastic resin sheet are in contact with each other, and separating the plate precursor from the thermoplastic resin sheet.

Production method of mold, manufacturing method of pattern sheet, production method of electroform, and production method of mold using electroform

A method of manufacturing a needle-like array sheet includes supplying a first needle-like array-forming solution consisting of an aqueous solution on a first mold having a first recess; interrupting drying in a wet state and forming a needle-like distal end part; supplying a second needle-like array-forming solution consisting of an aqueous solution on a second mold having a second recess; peeling a sheet part molding product, which is dried and solidified and has a protrusion corresponding to the second recess, after the sheet part molding product is formed; inserting the protrusion of the sheet part molding product into the first recess of the first mold; drying and solidifying the needle-like distal end part and the sheet part molding product after inserting the protrusion, bonding the needle-like distal end part and the protrusion of the sheet part molding product together, and forming a needle-like array sheet having the needle-like array.

Method of manufacturing needle-like array sheet

Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.

Method of producing transdermal absorption sheet

There is provided a method capable of manufacturing a mold at low cost, and a method of manufacturing a biocompatible pattern sheet by using the mold. The method of manufacturing a mold having a recessed pattern includes the steps of: forming a silicone resin film by applying a silicone resin solution to a surface of a model having a protrusion pattern; defoaming the silicone resin film by reducing the silicone resin film in pressure; forming the mold by heating and curing the silicone resin film while a base plate is in contact with a face of the silicone resin film, the face being opposite to the model; and releasing the mold from the model after releasing the base plate. The method of manufacturing a pattern sheet uses the mold.

Method of manufacturing mold and method of manufacturing pattern sheet

A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.

Method for manufacturing transdermal-absorption sheet

A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact.

Molding compact, and manufacturing method for transdermal absorption sheet

A minute convexo-concave pattern forming method includes: transferring a minute convexo-concave pattern of a mold to a resist layer of a transfer substrate where a resist layer is formed on a substrate and curing the transferred minute convexo-concave pattern; and after curing the transferred minute convexo-concave pattern, peeling the transfer substrate and the mold, the peeling step including: pressurizing a substrate back surface side of the transfer substrate with a peripheral part of the transfer substrate being fixed to bend the transfer substrate in a curved shape and starting peeling of the transfer substrate and the mold with a bending of the transfer substrate; and peeling a part of the minute convexo-concave pattern of the transfer substrate not peeled in the first peeling step by gradually decreasing a pressure for a pressurization so as to undo the bending of the transfer substrate.

Minute convexo-concave pattern forming method and forming device, and transfer substrate producing method and transfer substrate

Plaster and pressure sensitive adhesive tape

A method of fabricating a template () for a concave array mold () having a plurality of recesses of a high aspect ratio includes arranging a plurality of needles () in a mutually separated state and fixing the plurality of the arranged needles (). This method allows a template for a concave array mold having a high aspect ratio structure to be easily and inexpensively fabricated. Further, the thus fabricated template can be used to easily and inexpensively fabricate a concave array mold. Furthermore, a needle array sheet can be fabricated by injecting and fixing a resin solution into the concave array mold () and separating the cured resin solution from the concave array mold ().

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Kanagawa, Japan

Shotaro Ogawa