Chugai Seiyaku Kabushiki Kaisha

Shoshin Yoshida

Satoshi Tsuchiya

Masahiro Nishimoto

Atsushi Matsuo

Hirotaka Kashiwagi

Yoshikazu Nishimura

Satoshi Tanida

Masahide Aoki

Nobuyuki Hori

Hiroko Ogawa

Takahiro Kawai

Kyoko Oguri

Takuma Kamon

Tsutomu Sato

Hitoshi Yoshino

Yoshiyuki Furuta

Takuya Shiraishi

The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Pyrazolopyridine derivative having GLP-1 receptor agonist effect

The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

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Shizuoka, Japan

Shoshin Yoshida