Elan Pharmaceuticals, Inc.

Pharmacia & Upjohn Company

Pharmacia & Upjohn

Shon R Pulley

Varghese John

Ruth Elizabeth TenBrink

James Beck

John Alan Tucker

James Peter Beck

Michel Maillard

Jon S Jacobs

Roy K Hom

Robert Owen Hughes

Barbara Jagodzinska

Eric T Baldwin

John Nicholas Freskos

David Louis Brown

Louis Brogley

Lawrence Y Fang

Andrea Gailunas

Daniel H Rich

Brian Alan Sherer

Jose Aquino

Ruth Tenbrink

Joseph B Moon

Ruth T TenBrink

John Jacobs

Ying Zi Xu

Disclosed are compounds of the formula: where variables Z, X, R, R, R, and Rare defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.

Acetyl 2-hydroxy-1, 3-diaminoalkanes

The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Macrocycles useful in the treatment of alzheimer's disease

The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Substituted ureas and carbamates

The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R, Rand Rare as described in the specification.

3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines

The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Hydroxypropyl amides for the treatment of Alzheimer's disease

The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Benzamide 2-hydroxy-3-diaminoalkanes

The present invention is substituted amines of formula (X) and of the formula (X') useful in treating Alzheimer's disease and other similar diseases.

Compounds to treat Alzheimer's disease

The present invention is macrocycles of the formula (X):for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Macrocycles useful in the treatment of Alzheimer's disease

The present invention are macrocycles of the formula (IX):for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

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Hickory Corners, MI, United States of America

Shon R Pulley