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Shokichi Yuen

Kaname Sugimoto

The present invention relates to processes which are easily applicable for industrial production of Type II interferon and Type II interferon-containing agents. Particularly, the present processes are based on the invention that a large amount of high-titred Type II interferon is easily obtainable by transplanting established human cells in other warm-blooded animal body or inoculating the cells in a culture medium charged in a filter-membrane-interposed diffusion chamber which is designed and fitted in or to the animal body so that the cells can grow on its nutrient body fluid, multiplying the transplanted or inoculated cells in the warm-blooded animal body or the diffusion chamber utilizing the body fluid, then exposing the multiplied cells to the action of a Type II interferon inducer in vivo or in vitro to induce Type II interferon, and purifying and separating the induced Type II interferon. The agents containing Type II interferon obtained by the method disclosed herein are effective and superior for treating and preventing Type II interferon-sensitive diseases.

Type II interferon and agents thereof

The present invention relates to processes for an easily applicable industrial production of interferon and the possibilities of the products for preventing and treating interferonsensitive diseases. The process easily produces a large amount of interferon and transplanting established human cells to other warm-blooded animals or inoculating the cells in a diffusion chamber and multiplying the cells therein while allowing the animals to supply the cells with their nutrient body fluids, then exposing in vivo or in vitro the resultant cells to the action of interferon inducer. The present invention is also based on the discovery that the interferon obtained by the present method is an effective and superior preparation for preventing and treating interferon-sensitive diseases.

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Okayama, Japan

Shokichi Yuen