Meiji Seika Kabushiki Kaisha

Meiji Seika Kaisha, Ltd.

Shokichi Ohuchi

Kiyoaki Katano

Tomoaki Miura

Eiki Shitara

Hiroyuki Iida

Masaro Shimizu

Kazue Yaegashi

Midori Ishikawa

Yasuko Isomura

Kenji Asai

Emiko Hatsushiba

Takashi Tsuruoka

Mami Kawaguchi

Takashi Ando

Burton G Christensen

Arthur A Patchett

Seiji Shibahara

Takahiro Imai

Tsuneo Okonogi

Kazuko Kobayashi

Naoto Ohkura

Yasuyuki Ichimaru

Hisashi Suzuki

Kazumi Ota

Takashi Egawa

Seiji Tsutsumni

Kazumasa Aizawa

Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof

A .gamma.-diketone compound represented by the following formula (I) and a pharmaceutically acceptable salt and solvate thereof having platelet aggregation inhibitory activity is disclosed: ##STR1## wherein B is --Z--(CH.sub.2).sub.q COOR.sup.7 and A is the following group (II) or (III): ##STR2##

.gamma.-diketone compounds with inhibitory activity against platelet

Compounds with platelet aggregation inhibitor activity

.gamma.-Diketone compounds with inhibitory activity against platelet

A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: ##STR1## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i --COOR.sup.3,

Compound with platelet aggregation inhibitor activity

The invention relates to derivatives of pyrrolidin-2-ylcarbonylheterocyclic compound of the general formula ##STR1## in which R.sup.1 represents C.sub.1-6 alkyl, C.sub.1-20 cycloalkyl, aryl or heteroaryl,

Derivatives of pyrrolidin-2-ylcarbonylheterocyclic compounds

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Kanagawa-ken, Japan

Shokichi Ohuchi