Nippon Shinyaku Company, Ltd.

Shoji Yasufuku

Yoshihiko Yoshimoto

Masahiro Kise

Kichiro Inoue

Hironori Otsu

Yasuo Sasaki

Hiroki Fujieda

Masaaki Shirai

Hiroshi Fujisawa

Yoshihiko Makita

Kei Nakanouchi

A main object of the invention is to provide a novel useful vitamin Dderivative, which has an excellent vitamin Dactivity and, as compared with conventional vitamin Dderivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient. In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond: Y is a single bond, an alkylene, an alkenylene or phenylene; Rand Rare the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or Rand R, taken together with the adjacent carbon atom, form a cycloalkyl; Ris hydrogen or methyl; Z is hydrogen, hydroxy or &#x2014;NRR.

9, 10-secopregnane derivative and pharmaceutical

Tetrazole derivatives and drugs

Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 is cycloalkyl of 5 to 7 carbon atoms; aryl of 6 to 10 carbon atoms unsubstituted or substituted by straight or branched chain alkyl of 1 to 4 carbon atoms, halo or trifluoromethyl; or ##STR2## wherein A is oxygen, sulfur or NR.sup.5, wherein R.sup.5 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo, and R.sup.6 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo;

Acylphenol derivatives, useful as anti-inflammatory agents and pain

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Otsu, Japan

Shoji Yasufuku