Teijin Limited

Juridical Foundation the Chemo-Sero-Therapeutic Research Institute

Shoji Ono

Tsunemasa Yoshida

Yoji Suzuki

Yasuhiko Masuho

Atsushi Imaizumi

Hisao Yamaguchi

Shuzi Miura

Shuzo Sawada

Komei Ohashi

Akinobu Funatsu

Tetsuro Sato

Masaharu Kanesaki

A method of culturing microbes which belong to the genus Bordetella characterized by adding cyclodextrin or its derivative to the culture medium used for cultivating microbes belonging to the genus Bordetella and a culture medium therefor.

Culturing Bordetella in media containing etherified cyclodextrin

A method of the production of immunoglobulin having a high content of monr from immunoglobulin-containing materials by a fractionation method, which comprises carrying out the fractionation in the presence of a water-soluble, basic nitrogen-containing organic compound having a dissociation constant (pKb) of 7 or less or an acid addition salt thereof, and thereby inhibiting by-production of undesirable aggregated molecules. The immunoglobulin has a high content of monomer and contains no or little aggregated molecules and hence can be used as a medicine in immune prophylaxis and immunotherapy without undesirable side effects and can be administered by intraveneous route, and further, is useful for the preparation of chemically treated immunoglobulin having a high content of monomer.

Method of the production of immunoglobulin having high content of monomer

IgM derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in IgM up to 1-90% (acylation percentage)

IgM Derivatives and process for the preparation thereof

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Kodaira, Japan

Shoji Ono