Shiseido Company, Limited

Meiji Seika Kaisha, Ltd.

Shoji Nishiyama

Nobuto Minowa

Kenzo Ito

Kazue Sasaki

Hiroyuki Kuzuhara

Hiroyuki Kakoki

Michihiro Yamaguchi

Hideo Nakajima

Satoshi Tomomasa

Yoshimaru Kumano

Yasukazu Nakayama

Haruo Ogawa

Toru Okamoto

Kazuaki Suzuki

Toshihito Yabu

Shigetoyo Sawaki

Wataru Tokue

Kazufumi Naitoh

Katsuhisa Yamada

Yoichi Shimatani

Katsuya Baba

A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein Rrepresents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, Rrepresents lower alkyl, lower alkenyl, &#x2014;CHOR, formyl, &#x2014;COOR, or &#x2014;CHN(R)R, or Rand Rmay combine with each other to form &#x2014;O&#x2014;C(R)R&#x2014;O&#x2014;CH&#x2014;, Rand R, which may be the same or different, represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, &#x2014;N(R)R, formyl, &#x2014;COOR, or &#x2014;OR, or Rand Rmay combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH, or NH.

Triterpene derivatives and remedies for liver diseases

A solubilized cosmetic composition containing an ingredient which is difficult to be dissolved in water, an alkyl-modified carboxyvinyl polymer and a hydroxyalkylated cyclodextrin so as to solubilize the ingredient difficult to be dissolved in water and in particular substantially not containing a surfactant.

Solubilized cosmetic composition with a pharmaceutical or cosmetic agent, a methacrylate copolymer and a cyclodextrin

A pharmaceutical composition for treating a hepatic disorder, comprising a triterpene derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof is disclosed:

Triterpene derivatives and pharmaceuticals for treating hepatic disorders

A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (IV) or a salt thereof:

An anti-aging cosmetic composition in which is blended an enzymolyzed substance obtained by treating by one or more enzymes an alkali extract of a hypoallergenic rice obtained by treating rice in advance with a proteinase and, preferably, a UV protective agent.

Anti-aging cosmetic composition

The ultraviolet absorbing composition in accordance with the present invention comprises the following ingredients (A) and (B): (A) 4-tert-butyl-4'-methoxydibenzoylmethane; and (B) a diester which is liquid at 20.degree. C. and has a structure represented by the following general formula (1):

Ultraviolet absorbing composition

A cosmetic composition containing (i) a water-soluble polyhydric alcohol having two or more hydroxyl groups and/or a lecithin and (ii) a bivalent metal salt of an organic acid.

Suppressing stickiness to skin of cosmetic composition

An oil-in-water type emulsion composition comprising: an amphiphile and a surfactant selected from the substances which can form a gel in an amphiphatic substance-surfactant-water system at a temperature of not lower than ordinary temperatures; oil and water, wherein substantially the total amount of amphiphile and surfactant exist on the boundary surfaces of emulsion particles. The emulsion composition has both the physical properties close to those of an aqueous solution and a creamy feel at the time of use.

Oil-in-water type emulsion composition

A preparation for external application to the skin which comprises disodium adenosine triphosphate and tranexamic acid for prevention of skin roughening and skin improvement. The preparation further contains ginseng extract.

Cosmetic composition

A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.

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Yokohama, Japan

Shoji Nishiyama