Osaka University

Tao Health Life Pharma Co., Ltd.

Shoji Ideno

Yoshinobu Okuno

Kazuyoshi Ikuta

Motoki Kuhara

Ritsuko Koketsu

Mikihiro Yunoki

Masatoshi Oshita

Masatoshi Momota

Michio Sato

Koji Naito

Satoshi Horie

Munehiro Noda

Minako Hoshi

Hajime Horii

Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human influenza A virus subtype H3N2 or a human influenza B virus and has a neutralization activity against the virus. The human antibody is a human anti-human influenza virus antibody, which has a neutralization activity against a human influenza A virus subtype H3N2 and binds to a hemagglutinin HA1 region of the human influenza A virus subtype H3N2, or which has a neutralization activity against a human influenza B virus, and includes, as a base sequence of a DNA encoding a variable region of the antibody, a sequence set forth in any one of SEQ ID NOS: 5 to 12.

Human anti-human influenza virus antibody

An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid &#x3b2; fibrils or monomeric amyloid &#x3b2;-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid &#x3b2; fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid &#x3b2;-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.

Antibody and use thereof

Growing community of inventors

Osaka, Japan

Shoji Ideno