Sanraku-ocean Co., Ltd.

Shoji Hirata

Tomoyuki Ishikura

Yasuo Fukagawa

Kageaki Kouno

Kazuhiko Okamura

Yasutaka Shimauchi

Joseph Lein

Yasushi Okumura

A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl, and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.

Antibiotics and derivatives thereof having .beta.-lactamase inhibitory

A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.

Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory

Growing community of inventors

Fujisawa, Japan

Shoji Hirata