Japan Science and Technology Agency

Kagoshima University

Daiichi Seiyaku Co., Ltd.

Seikagaku Kogyo Kabushiki Kaisha

Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)

National University Corporation Kagoshima University

Shoichi Kusumoto

Yasuo Suda

Akio Arano

Michael Sobel

Koichi Fukase

Sumihiro Hase

Ichiro Azuma

Tetsuo Shiba

Yuichi Yamamura

Tsuneo Kusama

Masahiro Wakao

Tadamasa Hirayama

Hideki Hayashi

The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

Linker compound, ligand conjugate, and production methods thereof

A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound 

Linker compound, ligand, and producing method thereof

A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.

Versatile linker compound, ligand, and producing method thereof

2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.

Method of producing a conjugate utilizing a 2-amino-pyridine compound

2-aminopyridine compounds

Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,

Muramyldipeptide derivatives and process for the preparation thereof

Growing community of inventors

Osaka, Japan

Shoichi Kusumoto