Kikkoman Corporation

Shoichi Imai

Nobuyuki Yamaji

Shigehiro Kataoka

Motohiko Kato

Junko Isono

The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formula

N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphates and

A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.

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Kanagawa, Japan

Shoichi Imai