Nippon Shinyaku Company, Ltd.

Shoichi Chokai

Hiroshi Enomoto

Takayuki Ozaki

Hiromu Murai

Katsuya Ohata

Tomiyoshi Aoki

Katsuhide Saito

Yoshiaki Aoyagi

Yojiro Ukai

Masao Murase

Tadatoshi Nomura

Kichiro Inoue

Yoshiaki Yoshikuni

Yukio Fujita

Tatsuhiko Kono

Kyoichi Ideguchi

Mitsuhiro Maehara

Mitsuhiro Machara

Masahiro Adachi

Masahiro Kise

Kiyoshi Kimura

Ichiro Shirahase

Jun Segawa

Toshio Tomita

Haruo Tanaka

Hirotsugu Yoshida

Kenichi Nakamura

Koyishi Kimura

Shinji Ohmachi

Masafumi Taira

A pharmaceutical composition comprising a compound of the following general formula &lsqb;I&rsqb; or its salt.

Heterocyclic derivative and medicine

Derivatives of pyrimidine for treating acute cerebrovascular disorders

Pyrimidine derivatives and drugs

Benzofuran derivative and pharmaceutical composition

Indole derivatives and drugs

Pyroglutamide derivatives have been found to be useful as nootropic agents for administration to humans and animals.

Pyroglutamide derivatives

Compounds of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is hydrogen, halogen or alkyl and R.sup.2 is hydrogen or alkyl are useful to reduce serum lipids in animals, including humans.

Benzoic acid derivatives

Abietamide derivatives of the formula I ##STR1## wherein X is NZ wherein Z is hydrogen, alkyl, unsubstituted or substituted phenyl or X is a sulphur atom; when X is NZ, V is nitrogen, W is , and R is hydrogen or alkyl and when X is a sulphur atom, V is  , W is nitrogen, and R is hydrogen, alkyl, phenyl or --CH.sub.2 COOR'; wherein R' is hydrogen or alkyl and  is a single or double bond, are useful for treating hyperlipemia and particularly for the prevention and therapy of arteriosclerosis.

Abietamide derivatives

4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

4-quinolone derivatives having anti-inflammatory, anti-allergic,

3-methylflavone derivatives which are useful in the treatment of allergies, asthma and inflammation.

Methylflavone-8-carboxylates

4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

Pharmaceutically active 4-hydroxy-3-benzoyl-2-quinolone derivatives

A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.

Morpholinone derivatives and method of use

New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

Substituted N-(carboxymethyl)-3-aminopropan-2-ol derivatives

New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.

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Kyoto, Japan

Shoichi Chokai