Meiji Seika Kaisha, Ltd.

Shohei Yasuda

Yasuo Yamamoto

Takashi Ando

Takahiro Imai

Kunio Atsumi

Toshiro Sasaki

Eiki Shitara

Dai Kubota

Katsuhiko Noguchi

Nobuyuki Hori

Takeshi Murakami

Manabu Watanabe

Kenichi Kurihara

Koji Yanai

Tsuneo Okonogi

Keiichi Ajito

Kaoru Okakura

Yuji Tabata

Yumiko Okada

Kiyoshi Tanabe

Naoki Midoh

Koichi Miyamoto

Rie Shinei

Koreaki Imura

Shinichiro Tsujiyama

Kaori Miyajima

Kuniaki Tatsuta

The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner. 

Intermediates of 2-substituted carbapenem derivatives and process for production thereof

Disclosed is a process for efficiently producing a compound represented by formula (I): wherein Rrepresents aryl, amino, alkyl, or alkoxy; Rrepresents a protective group of the carboxylic acid; and Rrepresents an alkali metal, a hydrogen atom, alkyl, aryl, alkylsulfonyl, arylsulfonyl, or trialkylsilyl. This process is characterized by reacting a compound of formula (II) with a compound of formula (III) in the presence of a transition metal compound. 

Process for producing 1,2,3-Triazole compounds

An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing genes involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid, including a gene encoding an amino acid sequence (SEQ ID NO: 2) having 4-amino-4-deoxychorismic acid synthase activity, a gene encoding an amino acid sequence (SEQ ID NO: 4) having 4-amino-4-deoxychorismic acid mutase activity and a gene encoding an amino acid sequence (SEQ ID NO: 6) having 4-amino-4-deoxyprephenic acid dehydrogenase activity, so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof.

Transformant producing secondary metabolite modified with functional group and novel biosynthesis genes

Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progesterone-related diseases. Specifically, they are useful as abortifacients, oral contraceptive pills, carcinostatic agents for breast cancer and ovarian cancer, therapeutic agents for endometriosis, meningioma, and myeloma, and therapeutic and prophylactic agents for osteoporosis and climacteric disturbance.

Tetrahydronaphthofuranone derivatives and process for producing the same

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Odawara, Japan

Shohei Yasuda