Sumitomo Chemical Company, Limited

Hitachi Chemical Company, Ltd.

Research Development Corporation of Japan

Kanegafuchi Chemical Industry Co., Ltd.

Nippon Oil Seal Industry Co., Ltd.

Daicel Chemical Industries, Ltd.

Kansai Paint Company, Ltd.

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Shohei Inoue

Takuzo Aida

Atsunori Mori

Katsuhiko Isayama

Masayuki Yokoyama

Kazunori Kataoka

Noriko Yamada

Yasuhisa Sakurai

Michihide Honma

Tadamichi Takada

Nobuyuki Miyazaki

Masanori Yokokawa

Teruo Okano

Tsuyoshi Watanabe

Yoshitaka Ikeda

Chicara Kawamura

Masaki Kambe

Masahide Ishikawa

Koichi Kinoshita

Koichi Sanuki

Masakatsu Kuroki

Masaki Akatsuka

Masaki Kanbe

(S)-cyanohydrins are produced by asymmetric addition of hydrogen cyanide to aldehydes in the presence of a catalyst of cyclo-&lsqb;(S)-leucyl-(S)-histidyl&rsqb;.

Catalyst for asymmetric induction

This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded. The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on. The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof. Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.

Water soluble high molecular weight polymerized drug preparation

Disclosed are a lactone polymer, a carbonate polymer, a lactone-carbonate random or block copolymer which are mono-dispersed, that is, which have a molecular weight distribution of nearly 1, or, in which purity of a polymer component having a unitary structure is very high, and processes for the preparation thereof which comprise a ring-opening addition reaction of a lactone monomer and/or a cyclic carbonate monomer with a ring-opening initiator in the presence of an organic aluminum-based Lewis acid represented by general formula (I), ##STR1## wherein R is an alkyl group having a carbon number ranging from 1 to 4, Y is independently selected from a substituted group, and p is any one of 1, 2 and 3.

Monodispersed polymer or copolymer and a preparation process thereof

A living polymerization method in which an organic aluminum compound having a bulky substituent group is used as a cocatalyst in the living polymerization of a (meth)acrylic acid ester, an epoxide or a lactone in the presence of a metal porphyrin complex as a polymerization initiator.

Living polymerization method

A catalyst for asymmetric induction is provided which comprises an amino acid amide derivative represented by the formula [I]: ##STR1## wherein R.sup.1 represents an isopropyl group, etc., R.sup.2 and R.sup.3 are the same or different and each represents a lower alkyl group, etc., R.sup.4 represents a chlorine atom, etc., R.sup.5, R.sup.6 and R.sup.7 are the same or different and each represents a hydrogen atom, etc., and * denotes an abosolute configuration of S or R, and a titanium (IV) alkoxide. Optically active cyanohydrins are obtained in high yield and at high purity by addition of hydrogen cyanide to aldehyde compounds in the presence of the above mentioned catalyst.

Optically active cyanohydrins are prepared by addition of hydrogen cyanide to aldehydes in the presence of catalysts which comprise the dipeptide derivative represented by the formula ##STR1## wherein R.sup.1 represents an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a methyl group, a benzyl group or a phenyl group, R.sup.2 represents a benzyl group, an indol-3-ylmethyl group, an isopropyl group, an isobutyl group or a phenyl group, R.sup.3 represents a lower alkoxy group, a hydroxy group or a mono- or di-lower alkylamino group, R.sup.4 represents a hydrogen atom, or R.sup.2 and R.sup.4 are bonded together at their terminals to form a CH.sub.2 CH.sub.2 CH.sub.2 group, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are the same or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group or R.sup.5 and R.sup.6, R.sup.6 and R.sup.7, or R.sup.7 and R.sup.8 are bonded together at their terminals to form CH.dbd.CH--CH.dbd.CH or OCH.sub.2 O, and * denotes an absolute configuration of S or R, and a titanium (IV) alkoxide.

A polyalkylene oxide having unsaturated end groups. The polymer has a distribution of molecular weight Mw/Mn of not more than 1.5, and a process for the same. The polymer is useful as rubber materials, and can provide cured rubber having an excellent elongation.

Polyalkylene oxide having unsaturated end group and narrow molecular

Polypropylene oxide having unsaturated end groups is prepared by polymerizing alkylene oxide in the presence of a complex catalyst prepared by reacting an organoaluminum compound with a porphyrin compound and an active hydrogen-containing compound and converting at least one hydroxyl end groups into an unsaturated end group(s), the prepared polymer having a narrow distribution of molecular weight.

Process for preparing polyalkylene oxide having unsaturated end groups

A block copolymer having a narrow molecular weight distribution is produced by reacting an acid anhydride with an epoxide to yield a polyester, which is further reacted with a lactone, using a catalyst system comprising an aluminum porphyrin complex and an organic quaternary salt under mild reaction conditions.

Process for producing block copolymer

Polyalkylene oxide having narrow distribution of molecular weight is prepared by a process comprising polymerizing alkylene oxide in the presence of a complex produced by the reaction of an organoaluminum compound with a porphyrin compound and an active hydrogen-containing compound.

Process for preparing polyalkylene oxide having narrow distribution of

Polyesters having a narrow molecular weight distribution and block copolymers having a narrow molecular weight distribution obtained from said polyesters can be produced by using a catalyst system comprising an aluminum porphyrin complex and an organic quaternary salt under mild reaction conditions.

Process for producing polyester and block copolymer thereof

A copolymer having carbonate linkages is produced by copolymerizing an epoxy compound with carbon dioxide in the presence of an isoprene-magnesium complex compound or a reaction mixture of said complex compound with an active hydrogen compound as a catalyst. The catalyst has a much improved polymerization activity when treated with carbon dioxide in advance.

Process for producing copolymer having carbonate linkages

A catalyst composition and a process for preparing same comprising the reaction product of (a) an organo-metallic compound having the general formula R'nM, wherein n is an integer, at least one R' is an alkyl group, an alicyclic group, or halogen, hydroxy or alkoxy derivatives thereof, or hydrogen, the remaining R' groups are alkyl groups, alicyclic groups, alkaryl groups, aralkyl groups, aryl groups, or halogen, hydroxy or alkoxy derivatives thereof, and M is a metal of Group II or Group III of the periodic Table, (b) a co-catalyst component which is sulfur or a compound containing active hydrogen atoms, and (c) carbon dioxide. The catalyst composition is used in preparing copolymers of epoxy compounds with carbon dioxide.

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Shohei Inoue