Nitto-Denko Corporation

Aoyama Gakuin Educational Foundation

Shohei Horie

Kenjiro Mori

Eri Maeta

Yoshitsugu Matsumoto

Junji Kimura

Harumi Marushima

Chizu Sanjoba

Yasutaka Osada

Tatsuya Konishi

Shoichiro Saito

Tsuyoshi Mukobata

Masafumi Iwamoto

Takahiko Ito

Ryuhei Nagao

The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: wherein each symbol is as defined in the SPECIFICATION.

Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support

The invention provides a cut-out method capable of suppressing production of a byproduct, wherein the object RNA oligonucleotide is not cleaved from a universal linker, which is produced in cutting out the object RNA oligonucleotide from the universal support, and capable of increasing the yield of the object RNA oligonucleotide. The RNA oligonucleotide cut-out method includes a step of bringing a universal support supporting an RNA oligonucleotide in contact with an aqueous solution containing alkylamine and a monovalent inorganic salt.

Method of cutting out RNA oligonucleotide

Provided is an anti-leishmanial compound represented by formula (1): 

Anti-leishmanial compound and anti-leishmanial drug

Provided is an anti-leishmanial compound represented by formula (3): 

Growing community of inventors

Ibaraki, Japan

Shohei Horie