Kumamoto University

Denka Company Limited

Yamada Bee Company, Inc.

National University Corporation Kumamoto University

Shogo Misumi

Ryotaro Mitsumata

Takuma Gotanda

Nagisa Nakata

Naoki Kishimoto

Tomoki Tatefuji

Tomoki Ikuta

Hiroko Tani

Hiroshi Inooka

An inactivated whole-virus influenza vaccine may have its antibody-inducing ability is maintained or enhanced and may cause fewer side reactions. A method for preparing an inactivated whole-virus influenza vaccine may use an embryonated chicken egg method, including subjecting a virus solution including a whole influenza virus collected from embryonated chicken eggs to a hypotonic treatment.

Inactivated whole-virus influenza vaccine and method for preparing same

A mucosal adjuvant may have high mucosal immunogenicity and high safety and be useful in the preparation of mucosal vaccines, and a mucosal vaccine composition may include the same. Such mucosal adjuvant may include TGDK. A method for preparing the mucosal vaccine composition may include mixing TGDK with an immunogen.

Mucosal adjuvant

The present invention provides a mucosal immunomodulator comprising, as an active ingredient, at least one selected from the group consisting of compounds represented by the following formula (1), compounds represented by the following formula (2) and compounds represented by the following formula (3), and salts thereof. 

Mucosal immunomodulator

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Kumamoto, Japan

Shogo Misumi