University of Arkansas

Anthrogenesis Corporation

Anthrogenesis Corproation

Celularity Inc.

Shmuel Yaccoby

Sascha Dawn Abramson

Robert J Hariri

Mohammad A Heidaran

Xiaokui Zhang

Kristen S Labazzo

Ya-Wei Qiang

Marian Guelakis

John D Shaughnessy, Jr

Provided herein are methods of suppression of proliferation and growth of cells of bone-related cancers, e.g., multiple myeloma or chondrosarcoma cells, using placental cells, e.g., the placental stem cells described herein, and populations of such placental cells. Also provided herein are methods of treating individuals having cells of a bone-related cancer.

Treatment of bone-related cancers using placental stem cells

Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.

Methods and compositions for treatment of bone defects with placental cell populations

The present invention is drawn to methods of repairing lytic bone lesions and tumor growth in an individual. In this regard, the present invention discloses use of a Wnt ligand either alone or in combination with anti-Wnt signaling antagonist therapy. The individuals who might benefit from such method may include but are not limited to the ones with multiple myeloma, osteoporosis, post-menopausal osteoporosis, fractures, metastatic breast cancer or metastatic prostate cancer.

Overexpression of Wnt ligands and treatment of lytic bone diseases

Growing community of inventors

Little Rock, AR, United States of America

Shmuel Yaccoby