Ethrog Biotechnology, Ltd.

Yeda Research and Develpment & Co. Ltd

Life Technologies Corporation

Shmuel Cabilly

Uri Yogev

Ilana Margalit

Yehuda Shoenfeld

Miri Blank

Ephraim Katchalski-Katzir

Apparatus for conducting electrophoresis therein includes a chamber with a gel matrix. The chamber has a first sealed region and a second sealed region, and an anode within the first sealed region of the chamber and in contact with the gel matrix, and a cathode within the second sealed region and in contact with the gel matrix. At least one of the electrodes also provides ions for driving the electrophoresis. The apparatus further includes a matrix with at least one sparingly water-soluble salt.

Apparatus and method for electrophoresis

The present invention includes apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls wherein at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells. The present invention further includes apparatus for electrophoresis separation having a substantially closed electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in a stagger format. A device is provided for delivering samples into wells for molecular separation, having a flat surface with a top side and a bottom side, multiple loading sites on the top side arranged in standard format, multiple apertures on the bottom side arranged in stagger format and leading to the wells, and a channel through the flat surface connecting the loading sites to the apertures. The present invention provides a method for simultaneous loading of multiple samples into an electrophoresis apparatus, including the steps of providing an electrophoresis apparatus having an area with walls defining the area and a gel within the area having multiple wells arranged in stagger format, wherein the walls include apertures having loading sites and channels structurally configured to direct samples into the wells, loading the samples into the loading sites with a standard multiple loading mechanism, and conveying the samples from the loading sites to the wells.

Electrophoresis apparatus for simultaneous loading of multiple samples

Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (&#x3b2;2GPI) monoclonal antibodies (mAbs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-&#x3b2;2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.

Synthetic peptides and kits for diagnosis of anti-phospholipid syndrome

Synthetic peptides and derivatives thereof capable of inhibiting the biological activity of anti-beta-2-glycoprotein 1 (&bgr;2GPI) monoclonal antibodies (mabs) in vitro, and of inhibiting induction of experimental anti-phospholipid syndrome (APS) in mice by anti-&bgr;2GPI mAbs, are provided for the diagnosis and treatment of anti-phospholipid syndrome in humans.

Synthetic peptides and pharmaceutical compositions comprising them for diagnosis and treatment of anti-phospholipid syndrome

Apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls, at least one of the walls has apertures having loading sites, a gel located within the separation area, and a plurality of wells within the gel. The loading sites are offset with respect to the wells. The apertures are connected to the plurality of wells by channels structurally configured to convey samples from the apertures to the wells, and apparatus for electrophoresis separation having an electrophoresis area, an electrophoresis gel located within the electrophoresis area, and multiple rows of wells within the electrophoresis gel, wherein the rows are arranged in an alternating staggered format. A method for simultaneous loading of multiple samples into the electrophoresis apparatus.

Apparatus for conducting electrophoresis separation therein. The apparatus includes a chamber having therein a body of separating gel for carrying therein an electrophoresis separation and electrodes for connecting the chamber to an external electrical power source, thereby driving the electrophoresis separation. According to the invention at least one of the electrodes also providing ions for driving the electrophoresis separation. In one preferred embodiment, the apparatus is a cassette substantially closed before, during and after electrophoresis separation. According to an aspect of the invention the pH in the body of separating gel is substantially constant during the electrophoresis separation.

A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, at least one ion source having a volume smaller than the volume of the gel for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.

A substantially closed cassette for conducting therein electrophoresis separation which includes a closed chamber, the chamber includes therein a body of gel, means for providing ions for driving the electrophoresis separation and electrodes for connecting the cassette to an external electrical power source, thereby enabling to drive the electrophoresis separation.

Growing community of inventors

Gedera, Israel

Shmuel Cabilly