Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Shmuel Banai

Alexander Levitzki

Aviv Gazit

Gershon Golomb

Johannes Waltenberger

Frank D Boehmer

S David Gertz

David Gertz

PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same

PDGF receptor kinase inhibitory compounds of the quinoxaline family, methods for their synthesis and containment is slow release pharmaceutical preparations, and their use for treatment of proliferative malignant and non-malignant diseases or disorders by local or systemic application. A compound according to the invention includes a tyrphostin of the general formula: ##STR1## wherein R1 and R2 are each independently selected from the group consisting of alkyl, alkoxy, halogen, nitro and amine and Ar is selected from the group consisting of phenyl, ferrocene, thiophene, furane, pyrrole, indole, thiazole, imidazole and pyridine.

PDGF receptor kinase inhibitory compounds their preparation and

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Jerusalem, Israel

Shmuel Banai