Eisai Company, Limited

Mitsubishi Chemical Industries Limited

Eisai Ci., Ltd.

Shizuo Kuriyama

Noriyasu Hirose

Shigeru Souda

Kazutoshi Miyake

Yasuhiro Akiyama

Hidetoshi Kawashima

Kazuyasu Usuki

Mikio Saitoh

Kiyomi Yamatsu

Naoko Nagaoka

Naoko Sakabe

Akifumi Kitahara

Takeshi Uzuo

2-(4-Methylaminobutoxy)diphenylmethane or pharmaceutically acceptable salts thereof have been found to be useful as a pharmaceutical composition for improvement and/or treatment of mental symptoms caused by an organic disorder in the brain.

Treatment of mental symptoms caused by organic disorder in brain

A carboximide derivative represented by the general formula: ##STR1## wherein X is ##STR2## Z is alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkenyl or arylalkenyl, and Y is a substituted or unsubstituted pyridyl, pyrimidyl or phenyl group, and a pharmaceutically acceptable acid addition salt thereof. The carboximide derivative and acid addition salt are useful for treating diabetes and also for depressing the central nervous system. The carboximide derivative may be produced by reacting a sodium alkoxide represented by the general formula: ##STR3## wherein X and Y have the same meanings as defined above, with Z.Hal wherein Hal is a halogen and Z has the same meaning as defined above.

Carboximide derivative and medicines containing same

New phenothiazine derivatives having the general formula: ##STR1## wherein R represents a straight or branched alkyl group or alkenyl group having 5-15 carbon atoms, their acid addition salts and anti-psychotic drugs containing such new compounds.

Phenothiazine derivatives and anti-psychotic drugs containing the same

Pharmaceutical composition useful for improvement and/or treatment of

The carboximide derivatives of the formula: ##STR1## and pharmaceutically acceptable salts thereof; wherein X represents a group of the formula: ##STR2## Z represents a hydrogen atom or a group of the formula: ##STR3## wherein R represents an alkyl group, an aralkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an arylalkenyl group, a pyridyl group or a substituted amino group; Y represents an alkyl group, an aralkyl group, an aryl group, a substituted or unsubstituted pyridyl group, a substituted or unsubstituted pyrimidyl group or a benzothiazolyl group; and m represents an integer of 2 or 3 and processes for the production thereof. The derivatives and their salts possess hypoglycemic activity and are useful for treating diabetes.

Piperazine substituted carboxamide derivatives, compositions and method

New phenothiazine derivatives having the general formula: ##STR1## wherein R represents hydrogen atom or a lower alkyl group, and A represents a lower alkylene group, and process for the production thereof. The phenothiazine derivatives have remarkable activities against the central nervous system, and are useful as psychotropic drugs.

Psychotropic

Growing community of inventors

Saitama, Japan

Shizuo Kuriyama