Eisai Company, Limited

Shizuko Ohya

Shinro Tachibana

Kiyomi Yamatsu

Takeru Kaneko

Takahiro Nakazawa

Masuhiro Ikeda

Yoshihiro Arakawa

Seiji Yoshida

Kengo Araki

A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.

Analgesic peptide and process for the preparation thereof

A substance having opiate and analgesic activity is obtained from swine duodenum. The opioid substance of the present invention comprises a heptadecapeptide having the following primary amino acid structure: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln.

Heptadecapeptide

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Ushikumachi, Japan

Shizuko Ohya