Xdcexplorer (shanghai) Co., Ltd.

Shanghai Pharmaexplorer Co., Ltd.

Shanghai Epimab Biotherapeutics Co., Ltd.

Shiyong Gong

Lile Liu

Ying Zhang

Jian Yuan Wu

Chengbin Wu

Qing Duan

Shaoping Hu

Xinxiu Yang

Xuan Wu

Xiaolan Sun

Qin Zhong

Yizhen Yang

Lijuan Hao

Stewart Leung

Fei Peng

Tengjiao Xu

Yuzhu Chen

High-affinity antibodies recognizing Programmed Death Ligand-1 (PD-1) and Lymphocyte Activation Gene 3 protein (LAG-3) are disclosed. Binding sites from humanized anti-PD-1 and anti-LAG-3 antibodies are incorporated into a Fabs-in-Tandem Immunoglobulin format without significant loss of binding affinity, and the resultant bispecific, multivalent binding proteins are able to bind to both PD-1 and LAG-3 simultaneously. Such bispecific FIT-Ig binding proteins are useful for treatment of cancer.

High affinity antibodies to PD-1 and LAG-3 and bispecific binding proteins made therefrom

The present invention provides a humanized anti-TPBG antibody, a preparation method therefor, a conjugate thereof, and applications. The humanized anti-TPBG antibody comprises: (a), a framework region comprising a residue of a human antibody framework region; and (b) one or more CDRs of a light-chain variable region as shown in the SEQ ID NO:4 or 8 or one or more CDRs of a heavy-chain variable region as shown in the SEQ ID NO:2 or 6.

Humanized anti-TPBG antibody, preparation method therefor, conjugate thereof, and applications

The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.

IL-13 antibody and preparation method and use thereof

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Shanghai, China

Shiyong Gong