Chinese Academy of Sciences

Nantong University

Chongqing Rato Technology Co., Ltd.

Shiying Li

Zhongmin Liu

Wei Huang

Songlin Zhou

Xiaosong Gu

Fei Ding

Yunpeng Xu

Xin Tang

Danhua Yuan

Yumin Yang

Bin Yu

Luzhong Zhang

Yun Gu

Hualin Sun

Guangye Liu

Yanan Liu

Changmin Bai

Zhaoan Chen

Yaxian Wang

Wenlong Lan

A catalyst for pyrolysis of 1,2-dichloroethane (1,2-DCE) to prepare vinyl chloride monomer (VCM), a preparation method, a use, and a regeneration method thereof are provided. The catalyst for pyrolysis of 1,2-DCE to prepare VCM includes a silicon-aluminum molecular sieve. The catalyst for pyrolysis of 1,2-DCE to prepare VCM has high reaction activity and excellent selectivity and solves the problem that the pyrolysis of 1,2-DCE to prepare VCM in the prior art involves high reaction temperature and large energy consumption and is prone to coking and carbon deposition.

Catalyst for pyrolysis of 1,2-dichloroethane (DCE) to prepare vinyl chloride (VC) and preparation method, use, and regeneration method thereof

Provided is a use of one or more MicroRNA genes selected from miRNAs of Family Let-7, miR-21 or miR-222 in the construction of tissue engineered nerves and in the repair of peripheral nerve defects. An outer and/or internal surface or pores of a tissue engineered nerve graft are coated or adsorbed with polymeric nanomicrospheres carrying a Let-7 family miRNA inhibitor, miR-21, or miR-222, or a mimetic thereof, wherein the polymeric material is composed of biocompatible fibronectin and heparin. The regeneration of peripheral nerves and the construction of tissue engineered nerves are promoted by regulating the expression of MicroRNA genes which can effectively promote the proliferation of primary Schwann cells cultured in vitro and have an anti-apoptotic effect on neuronal cells. In-vivo test proves that bridging of the tissue engineered nerve graft can facilitate the regeneration of peripheral nerves, thus being useful in the treatment of peripheral nerve injury.

Construction of MicroRNA gene-mediated novel tissue engineered nerve and applications thereof in repairing nerve defect

Growing community of inventors

Jiangsu, China

Shiying Li