Ampsource Biopharma Shanghai Inc.

Shandong New Time Pharmaceutical Co., Ltd.

Shixiang Jia

Qiang Li

Si Ruo Chen

Yuanli Li

Xinlu Ma

Zhao Dong

Guimin Zhang

Yuan Yan

Yuhua Zhang

Chi Zhou

Jiyu Zhang

Lili Zhao

Zhenyu Li

Bin Li

Zhong Liu

Xiong Feng

Xingxia Hu

Li Zhou

Xueyuan Cui

Lingju Yu

Yao Xiong

Yujie Yan

Yingying Jin

Rilong Sun

Xuemei Liu

Jiasheng Diao

The invention provided herein relates to methods and uses of a bispecific antibody, which specifically binds the surface antigen CD3 of immune cells and the BCMA antigen on the surface of tumor cells and which may bind to human CD3 with high affinity, induce T cell proliferation, and mediate tumor cell killing effects. The bispecific antibody may be used to mediate the T cell-specific killing of target cells in in vitro tests.

Bispecific antibody binding BCMA and CD3

The present disclosure relates to a dual-function protein for regulating blood glucose and lipid metabolism, wherein said dual-function protein comprises a human GLP-1 analog and human FGF21. In the present disclosure, provided is a method for preparing said dual function protein, and also provided is the use of said dual-function protein in the preparation of a biological substance for treating type 2 diabetes, obesity, dyslipidemia, fatty liver disease and/or metabolic syndrome. The dual-function protein provided in the present disclosure can synergistically regulate blood glucose and lipid levels in vivo, and satisfy multiple requirements for patients with type 2 diabetes such as lowering blood glucose, relieving hepatic steatosis, reducing body weight and improving metabolic disorders of circulating lipids.

Dual-function protein for lipid and blood glucose regulation

Growing community of inventors

Shanghai, China

Shixiang Jia