Johnson and Johnson Vision Care, Inc.

Other

J&j Vision Care, Inc.

Johsnon & Johnson Vision Care, Inc.

Shivkumar Mahadevan

Azaam Alli

Charles W Scales

Scott L Joslin

Dola Sinha

Frank Molock

Patricia Martin

James D Ford

Stephen C Arnold

Kunisi Venkatasubban

Thomas Maggio

Zohra Fadli

Yong Zhang

Randall Braxton Pugh

Frederick A Flitsch

David Curtis Turner

Adam Toner

Daniel B Otts

James Daniel Riall

Leilani Keahi Sonoda

Carrie L Davis

Douglas G Vanderlaan

Ghulam Maharvi

Donnie Jerome Duis

Dawn D Wright

Fang Lu

Eric R George

Brian Aitken

Ranganath Ramakrishnan Raja

Leah Hansen

Barry Van Gemert

Kevin P McCabe

Wenjing Xiao

Brent Matthew Healy

Kathrine Osborn Lorenz

Frank F Molock, Jr

Osman Rathore

R Sridharan

C Surendran

Sharmila Muthukrishnan

Michael Francis Widman

Diana Zanini

Kristy L Canavan

Michelle Carman Turnage

Thomas R Karkkainen

Ronald J Clark

Vandeeta Khanolkar

Frank F Molock

Robert S Ward

Gregory A Hill

Scott Frederick Ansell

Vincent Henri Barre

Jonathan Patrick Adams

Adam C Reboul

Xin Wei

Stephen C Pegram

Dominic P Gourd

Dharmesh K Dubey

Alexander Guzman

John C Heaton

Derek Dean Nankivil

Michael G Tokarski

Michael R Clark

Jaqunda Patton

Shanger Wang

Minghan Chen

John R Buch

Yuan Tian

Xiaoping Lin

Michael J Lopez

Carrie L Caison

Terry L Spaulding

Thomas R Rooney

Brian Pall

Andrew J Wagner

Jie Xu

Hemantkumar Vashi

Nayiby Alvarez

Joseph R Hepting

James M Serpilio, Jr

Joseph Hepting

Jeffery S Longo

Jason Garner

Katherine Osborn Lorenz

Brain Pall

Azaam Alti

Lenora C Copper

Osman Rathorne

David Turner

Kevin P Mccabe

Jr Frank F Molock

Azaam Ali

Xiao Wenjing

Eric George

Gina M Cullerton

Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Multifocal contact lens displaying improved vision attributes

Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

Polymer compositions containing grafted polymeric networks and processes for their preparation and use

Described are polymerizable high energy light absorbing compounds of formula I: wherein R, R, R, R, R, R, R, R, R, and X are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Polymerizable absorbers of UV and high energy visible light

Provided are imidazolium zwitterion polymerizable compounds and their applications in ophthalmic devices and packaging solutions. The zwitterionic polymerizable compounds are of formula I:

Imidazolium zwitterion polymerizable compounds and ophthalmic devices incorporating them

Provided are amino acid based polymerizable compounds and their applications in ophthalmic devices. The amino acid based polymerizable compounds are of formula I: wherein R, R, and Rare as described herein.

Amino acid-based polymerizable compounds and ophthalmic devices prepared therefrom

Described are visible light absorbing compounds. The compounds absorb various visible light wavelengths, such as in the region of 500 to 625 nm, and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Transition metal complexes as visible light absorbers

A method or use of a contact lens, includes applying to at least one eye of a contact lens wearer the contact lens that is a free radical reaction product of a reactive mixture that includes one or more polymerizable compounds suitable for making the contact lens; and a high energy visible (HEV) light absorbing compound; and improving, by the contact lens, at least one clinical attribute comprising overall preference of the contact lens while using computer screens and digital devices as observed by the contact lens wearer, comfort at the end of the day, CLUE Comfort score, CLUE Vision score.

Contact lens displaying improved vision attributes

Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R, R, R, R, and Rare as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Described are visible light absorbing compounds. The compounds have a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 100 nanometers, wherein the compounds are photostable. The compounds substantially mimic the visible light absorbance properties of macular pigment while remaining photostable. The compounds may be used in a variety of articles, including ophthalmic devices.

Photostable mimics of macular pigment

The present invention relates to a method of manufacturing a contact lens including the steps of: (i) adding reactive components to a mold, wherein the reactive components comprise (a) at least one hydroxy-containing silicone component having a weight average molecular weight from about 200 to about 15,000 g/mole and (b) at least one mono-ether terminated, mono-methacrylate terminated polyethylene glycol having a weight average molecular weight from about 200 to about 10,000 g/mole; (ii) curing the reactive components within the mold to form the contact lens; and (iii) removing the contact lens from said mold.

Method of making silicone containing contact lens with reduced amount of diluents

Provided are compounds that may function as functionalized polymerization initiators, for instance in the manufacture of ophthalmic lenses, and to methods of such manufacture. The compounds are of formula I: wherein R, R, R, R, R, T, p, q, and n are as defined herein.

Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses

Various non-limiting embodiments of the present disclosure relate to ophthalmic devices comprising photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates ophthalmic devices comprising photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety. Other non-limiting embodiments of the present disclosure relate to methods of making the photochromic ophthalmic device, wherein the photochromic ophthalmic devices comprise the photochromic naphthopyrans described herein.

Ophthalmic devices comprising photochromic materials with reactive substituents

Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use

Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Growing community of inventors

Orange Park, FL, United States of America

Shivkumar Mahadevan