Wockhardt Limited

Shivkumar Agarwal

Mahesh Vithalbhai Patel

Nitin Shetty

Noel John De Souza

Sreenivas Kandepu

Ravindra Dattatraya Yeole

Satish B Bhawsar

Dilip J Upadhyay

Habil Fakhruddin Khorakiwala

Nishith Chandra Chaturvedi

Rupinder K Beri

Abraham Thomas

Noel J De Souza

The present invention relates to optically pure S-(&#x2212;)-benzoquinolizine carboxylic acid, lysine salt and to pharmaceutical compositions comprising the S(&#x2212;)-benzoquinolizine carboxylic acid, lysine salt.

Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment

The present invention relates to optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(&#x2212;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.

The invention relates to the new arginine salt forms of S-(&minus;)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo&lsqb;i,j&rsqb;quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.

Chiral fluoroquinolone arginine salt forms

The present invention relates to optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(&plus;)-isomers, to processes for preparation of the optically pure S-(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(&plus;)-isomers, and to pharmaceutical compositions comprising the S(&minus;)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions can be used to systemically and topically treat bacterial Gram-positive, Gram-negative and anaerobic infections, specially resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and emerging nosocomial pathogen infections, while avoiding toxic effects associated with the administration of the racemic mixture of RS-(&plusmn;)-benzoquinolizine carboxylic acid. The compounds and compositions of this invention can also be used to treat diseases and disorders caused by Gram-positive, Gram-negative and anaerobic bacteria, and diseases and disorders caused by resistant Gram-positive organisms, Gram-negative organisms, mycobacteria and nosocomial pathogens.

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Aurangabad, India

Shivkumar Agarwal