Fresenius Kabi Ipsum S.r.l.

Teva Pharmaceutical Industries Limited

Shivaji Haribhau Shelke

Walter Cabri

Saswata Lahiri

Jacopo Zanon

Govind Singh

Antonio Ricci

Nitin Kumar

Madan Singh

Vinod Kumar Kansal

Brijnath P Chaurasia

Anand Prakash Tiwari

Shridhar Reddy

Tapanjyoti Biswal

The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-&#x3b3;-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.

Process for the preparation of sugammadex

The present application provides crystalline forms of 6-per-deoxy-6-per-chloro-&#x3b3;-cyclodextrin, and polymorphs thereof. The present application also provides methods for preparing said polymorphs by dissolving 6-per-deoxy-6-per-chloro-&#x3b3;-cyclodextrin in dimethylformamide and using an anti-solvent of a water/alcohol mixture.

Crystalline forms of per-chloro-&#x3b3;-cyclodextrines

Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a Caromatic group, R is a straight or branched Calkyl, ester, or carboxylic acid, and Ris a straight or branched Calkyl, aralkyl, or substituted aralkyl.

Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid

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Maharashtra, India

Shivaji Haribhau Shelke