Tanabe Seiyaku Company, Limited

Shiu-Lan Chiang

Thomas J Lobl

Pina M Cardarelli

Wolfgang Scholz

Nancy Delaet

The present invention describes cyclic peptide compounds which modulate integrin mediated adhesion. These compounds can inhibit both .beta..sub.1 and .beta..sub.2 mediated adhesion. The invention further relates to therapeutic uses for these compounds in the treatment of adhesion related pathologies.

Cyclic peptide inhibitors of .beta..sub.1 and .beta..sub.2

Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion, including adhesion related to fibronectin, as well as leukocyte adhesion to endothelial cells, are disclosed. Methods for synthesizing, testing, formulating, and using the compounds as therapeutic agents are also disclosed.

Cyclic cell adhesion modulation compounds

Cyclized integrin receptor antagonist compounds useful in modulating cell adhesion to integrin receptors, including adhesion related to fibronectin and/or fibronectin receptors, are disclosed. Methods for synthesizing, testing, formulating, and using the compounds as therapeutic agents are also disclosed.

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San Diego, CA, United States of America

Shiu-Lan Chiang