The Green Cross Corporation

Shirou Komeda

Yasuo Ueda

Yoshio Kagitani

Kenji Tanaka

Kazumasa Yokoyama

Satoshi Funakoshi

Satoshi Morimoto

Kozi Munechika

An alkali metal hydrogensulfite or sulfite is effective for controlling a local injury such as inflammation and vein injury occurring on the injection of an antitumor benzodiazepine compound of the formula ##STR1## wherein R.sub.1 denotes hydrogen atom, or acyl, carbamyl, or alkoxycarbonyl group; R.sub.2 denotes hydrogen atom or acyl group; and R.sub.3 denotes sulfinic acid rest, SO.sub.2 X, or sulfonic acid rest, SO.sub.3 X, X meaning hydrogen, alkali metal or alkaline earth metal. An aqueous solution containing the both can be administered by injection.

Injectable aqueous solution containing hydrogensulfite and/or sulfite

The drug such as antitumor agents or antibiotics can preferentially be carried to a morbid part, for example, injured tissue and tumor site by administering its complex with fibronectin combined through an oxidized dextran to repair the morbid part. The complex is prepared by reacting the drug, an oxidized dextran having a cleaved structure of aldohexopyranose ring, and fibronectin.

Fibronectin-dextran-drug complex and method of preparation thereof

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Tondabayashi, Japan

Shirou Komeda