Asahi Kasei Kogyo Kabushiki Kaisha

Asahi Kasei Pharma Corporation

Drug Delivery System Institute, Ltd.

Asahi Pharma Corporation

Shiro Miyoshi

Kohei Ogawa

Shunichi Ikuta

Satoru Nakabayashi

Hitoshi Yamauchi

Akiro Kajihara

Toshinori Ishizuya

Kunio Higashi

Compounds of the general formula (I): or a salt thereof, wherein Ris a hydrogen atom or the like; Ris NHSORor the like; Ris a (C-C)alkyl group or the like; Ris a hydrogen atom or the like; Rand Rmay be the same or different and are each independently a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Zto Zare a carbon atom or the like; n is an integer of 0 to 6; *1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when Ris other than a hydrogen atom.

Indazole compounds as B3 adrenoceptor agonist

A novel compound represented by the following formula (1) or a salt thereof: wherein symbol 'A' represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two heteroatoms in the ring, a group represented by the formula A1 (R, R, and Rrepresent hydrogen atom, hydroxyl group, etc.), etc., B represents a group represented by the formula B1 (Rrepresents hydrogen atom, hydroxyl group, etc.), etc., Rrepresents an alkyl group, and symbol 'n' represents an integer of 2 to 6, which has a parathyroid hormone depressing action and showing low toxicity, and a medicament containing the compound or salt thereof as an active ingredient.

Bicyclic compound

Indazole compounds as &#x3b2;3 andrenoceptor agonist

A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. Rrepresents NHSOR, etc., provided that Rrepresents Calkyl, etc. Rrepresents hydrogen, etc. Rand Rmay be the same or different and each independently represents hydrogen, etc. X represents oxygen, etc. Y represents oxygen, etc. Zto Zeach represents carbon, etc. n is an integer of 0 to 6 and ast1 indicates that the carbon atom is asymmetric, and *2, in the case where Ris not hydrogen, indicates that the carbon atom is asymmetric or a salt of the compound.

Indazole compounds as &#x3b2;3 adrenoceptor agonist

Compounds of the general formula (I):or a salt thereof, wherein Ris hydrogen, hydroxyl or halogen; Ris NHSOCH, SONHCHor the like; Rand Reach independently is hydrogen, Calkyl, optionally substituted phenyl or optionally substituted benzyl; X is NH, sulfur, oxygen or methylene; Y is oxygen, NR, sulfur, methylene or a bond; and * represents an asymmetric carbon atom. The compounds are useful as a medicine for treating or preventing diabetes, obesity, hyperlipidemia, digestive diseases, depression or urinary disturbances.

Bicyclic compounds

Compounds having a &bgr;-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and their intermediates, wherein R represents hydrogen or methyl; R represents hydrogen, halogen, hydroxy, benzyloxy, amino, or hydroxymethyl; R represents hydrogen, hydroxymethyl, NHR , SO NR R , or nitro; R represents hydrogen or lower alkyl; and X represents methylene, R represents hydrogen, one of R and R represent hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy.

Tricyclic compounds and drug compositions containing same

Compounds having a &bgr;-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and their intermediates, wherein R represents hydrogen or methyl; R,represents hydrogen, halogen, hydroxy, benzyloxy, amino, or hydroxymethyl; R,represents hydrogen, hydroxymethyl, NHR,, SO,NR,R,, or nitro; R,represents hydrogen or lower alkyl; and X represents nitrogen, R,represents hydrogen, one of R,and R,represent hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy.

Tricyclic compounds and drug compositions containing the same

Tricyclic compounds having saturated rings and medicinal compositions containing the same

Disclosed is a sulfonamide derivative represented by following formula (I) and a medicine for the treatment of asthma comprising the sulfonamide derivative as an active ingredient which exhibits bronchodilation effect. ##STR1## wherein X represents a quinoline residue represented by formula (II) or an isoquinoline residue represented by formula (III) ##STR2## where R.sup.1 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, or ##STR3## where R.sup.2 is a hydrogen atom or a hydroxyl group, and wherein: when X is quinoline residue (II), n is zero or 1, in which,

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Fuji, Japan

Shiro Miyoshi