Applied Research Systems Ars Holding N.v.

Shirley Vui Yen Cheng

Christie Ann Kelton

Noreen P Nugent

Rene Lynn Schweickhardt

The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present invention also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating patients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.

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Boston, MA, United States of America

Shirley Vui Yen Cheng