Zymogenetics, Inc.

Other

Osteoscreen, Inc.

Osteoscreen Ip, LLC

Shirley R Gasper

Patricia A McKernan

Robert R West

Nand Baindur

Virender M Labroo

Kirk G Robbins

Theresa Martinez

Gregory R Mundy

Charles R Petrie

James R Piggott

Colin Lellis

Lennie Chen

The topical administration of statins for the treatment of bone disorders is disclosed.

Topical administration of statins for treatment of bone disorders

Isoprenoid pathway inhibitors for stimulating bone growth

Various embodiments of statin compounds are shown to enhance the formation of bone and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.

Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C; Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; and R' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6 C; and the dotted lines represent optional .pi.-bonds, promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. These compounds can be used in combination with other bone growth-promoting compounds and/or estrogens and/or bisphosphonates for this purpose.

Compositions and methods for stimulating bone growth

Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C;

The invention provides isolated, biologically active native calcitonin mimetics and related methods. These small 16 and 17 amino acid proteins mimic the interaction of calcitonin on its receptor, and also exhibit bone resorptive inhibiting activity.

Native calcitonin mimetics

Growing community of inventors

Seattle, WA, United States of America

Shirley R Gasper