Colgate Palmolive Company

Ortho Pharmaceutical Corporation

Shirley M Ng

James A Mezick

Richard K Farng

Susan E Wieckowski

Denise-Marie DiTomasso

Stanley B Wrobel, Jr

Gerard J Gendimenico

This invention relates to aqueous gel retinoid compositions and their methods of use. More specifically, the aqueous gel retinoid compositions of the invention utilize micronized particles of retinoids, particularly tretinoin, to provide an aqueous gel for topical application of such retinoids to the skin which minimizes skin irritation while retaining drug efficacy.

Aqueous gel retinoid dosage form

A stable aqueous hydrogen peroxide dental gel for oral cleaning and anti-gingivitis application having an acid pH of about 4.5-6, comprising about 18-25% by weight of a solid flake or powder poly-oxyethylene polyoxypropylene block copolymer gelling agent, hydrogen peroxide, about 15-40% by weight of a polyethylene glycol humectant, flavor, or sweetening agent such as sodium saccharine, and a nonionic surfactant, as the essential ingredients. Distilled (deionized) water is preferred to prevent minimal contamination.

Stable hydrogen peroxide dental gel

A stable aqueous hydrogen peroxide gel dentifrice for oral anti-gingivitis application having an acid pH of about 3-6 comprising a combination of hydrophilic and hydrophobic fumed silica gelling agent, hydrogen peroxide, about 20-40% by weight of a polyethylene glycol humectant, flavor, sweetening agent, sodium benzoate, and a nonionic surfactant as the essential ingredients, prepared by a process which comprises controlling the order of addition of the essential ingredients. Distilled (deionized) water is preferred in the formulation to prevent minimal contamination.

Stable hydrogen peroxide dental gel containing fumed silicas

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Bridgewater, NJ, United States of America

Shirley M Ng